Including learning experience
2009–2014 PhD in Polymer Chemistry and Physics Shanghai Jiao Tong University, China
2006–2009 MSc in Polymer Chemistry and Physics Donghua University, China
2002–2006 BSc in Materials Science Wuhan Textile University, China

 

Work Experience
Nov. 2020–now, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, China. Associate Professor (Doctoral Advisor)
Jun. 2015–Oct. 2020, Department of Chemical Engineering, Imperial College London, UK. Research Associate
Sep. 2014–May 2015, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, China. Postdoctoral Research Fellow

 

Talent Awards
2021 Shanghai High-Level Overseas Talents Introduction Program
2019 2019 Sir William Wakeham Award (by Imperial College London)
2019 Oral Presentation Prize at Euro Biomaterials 2019
2017 Oral Presentation Prize at 24th CSCST-SCI conference (by Society of Chemical Industry)
2014 Outstanding Graduate (by SJTU)
2014 Special Award of State Key Lab. of Metal Matrix Composites Scholarship (by SJTU)
2014 First-Class OMRON Scholarship (by OMRON Corporation)
2013 First Award of State Key Lab. of Metal Matrix Composites Scholarship (by SJTU)
2013 First Award of “ZHAOZHUMULAN” Scholarship (by SJTU)
2012 Academic Youth Award for Doctoral Candidate (by Ministry of Education, China)
2012 National Scholarship for Excellent Doctoral Student (by Ministry of Education, China)
2012 Outstanding Doctoral Dissertation Cultivation Fund (by SJTU)
2012 Special Award of State Key Lab. of Metal Matrix Composites Scholarship (by SJTU)
2012 Outstanding Graduate Student Scholarship (by SJTU)
2008 Excellent Social Practice Scholarship (by Donghua University)
2007 First Award of the Eleventh Academic Thesis Competition (by Donghua University)
2006 Second Award of Outstanding Bachelor's Degree Thesis (by Hubei Province, China)

 

Social Service
1. Early-Career Editorial Board member of Environmental Science & Ecotechnology (IF = 9.371)
2. Guest Editor of Frontiers of Chemical Science and Engineering (IF = 4.803)
3. Guest Editor of Molecules (IF = 4.927)
4. Guest Editor of Frontiers in Chemistry (IF = 5.221)
5. American Chemistry Society (ACS) membership, Royal Society of Chemistry (RSC) membership, Society of Chemical Industry (SCI) ambassador and membership, Chinese Chemical Society (CCS) membership, etc.
6. Reviewers for ACS Macro Letters, Macromolecules, Langmuir, Scientific Reports, Polymer Chemistry, Chemistry-A European Journal, etc.

Our research interests focus on the design, synthesis and functionalization of myriad precision, sequence-defined polymeric biomaterials with multiple dimensions, and their applications in a wide spectrum of biological fields. The goal of our research is to establish a comparable set of rules that can be utilized for the fabrication of precision, well-defined nanoscale delivery systems with controlled properties and functions, and optimized therapeutic efficacy. This will not only be fundamental science in its own right, relevant to a broad range of chemical problems, but it will also be a platform technology that can be implemented in numerous biological and materials applications.
Our research areas mainly include:
1. To establish a fully automatic flow chemistry synthesis platform for the production of myriad precision, sequence-defined natural/synthetic polymeric biomaterials;
2. To create a precision protein functionalization technology and aim at the design and development of functional protein bioconjugates, and precision control of their hierarchical architectures in solution via sequence-relevant noncovalent recognition, further achieving improved clinical immunotherapy;
3. To exploit a wide range of well-defined nonviral vectors for safe, efficient, and targeted delivery of therapeutic genes in vivo, further achieving comparable or even superior gene therapy efficiency than conventional viral vectors;
4. To fabricate one-dimensional, two-dimensional, sequence-defined conjugated polymeric materials for bioimaging in vivo and electronic devices.

1. Li Yu†*, Baiyang Chen†, Ziying Li, Qijing Huang, Kaiyuan He, Yue Su,* Zeguang Han, Yongfeng Zhou, Xinyuan Zhu, Deyue Yan and Ruijiao Dong*. Digital synthetic polymers for information storage. Chemical Society Reviews 2022, Submitted. (* Corresponding author)
2. Wumaier Yasen*, Bei Li, Aliya Aini, Linzhu Zhou*, Dongbo Guo, Qiuhui Qian, Dong Chen, Xinyuan Zhu, Ruijiao Dong*. Visible light-guided gene delivery with nonviral supramolecular block copolymer vectors. ACS Applied Materials & Interfaces 2022, Submitted. (* Corresponding author)
3. Siyao Li, Ruijiao Dong, Valentina-Elena Musteata, Jihoon Kim, Neel D. Rangnekar, J. R. Johnson, Bennett D. Marshall, Stefan Chisca, Jia Xu, Scott Hoy, Benjamin A. McCool, Suzana P. Nunes, Zhiwei Jiang*, Andrew G. Livingston*. Hydrophobic polyamide nanofilms provide rapid transport for crude oil separation. Science 2022, 377, 1555–1561. (IF = 63.714) Highlighted by ScienceDaily, NatureAsia, MirageNews and X-MOL
4. Zhiwei Jiang†, Ruijiao Dong†, Austin M. Evans, Niklas Biere, Mahmood A. Ebrahim, Siyao Li, Dario Anselmetti, William R. Dichtel, Andrew G. Livingston*. Aligned macrocycle pores in ultrathin films for accurate molecular sieving. Nature 2022, 609, 58–64. († Co-first Author) (IF = 69.504) Highlighted by ScienceMag, MirageNews, Phys.org and X-MOL
5. Weiping Wu*, Xiaolei Fan*, Yongliang Li*, Ruijiao Dong*. Growing collaborations between Chinese and UK young scholars on chemical science and technology. Front. Chem. Sci. Eng. 2021, 15(1), 1–3. (Editorial, Guest Editor) (IF = 4.803)
6. Ruijiao Dong, Ruiyi Liu, Piers R. J. Gaffney, Marc Schaepertoens, Patrizia Marchetti, Christopher M. Williams, Rongjun Chen, Andrew G. Livingston*. Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving. Nature Chemistry 2019, 11, 136–145. Highlighted by IChemE; Highlighted by X-MOL; Imperial College News (IF = 24.274)
7. Ruijiao Dong, Yongfeng Zhou, Xiaohua Huang, Xinyuan Zhu*, Yunfeng Lu, Jian Shen*. Functional supramolecular polymers for biomedical applications. Advanced Materials 2015, 27, 498–526. ESI Highly Cited Paper; One of the Most-Read Articles (November, 2014) (IF = 32.086)
8. Ruijiao Dong, Yongfeng Zhou, Xinyuan Zhu*. Supramolecular dendritic polymers: From synthesis to applications. Accounts of Chemical Research 2014, 47, 2006–2016. One of the Most-Read Articles (May, 2014) (IF = 24.466)
9. Ruijiao Dong, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. "Breathing" vesicles with jellyfish-like on–off switchable fluorescence behavior. Angewandte Chemie-International Edition 2012, 51, 11633–11637. Highlighted by ACS “Noteworthy Chemistry” (IF = 16.823)
10. Wumaier Yasena, Ruijiao Dong*, Aliya Aini, Xinyuan Zhu*. Recent advances on supramolecular block copolymers for biomedical applications. Journal of Materials Chemistry B 2020, 8, 8219-8231. (* Corresponding author) (IF = 7.571)
11. Wumaier Yasen, Ruijiao Dong*, Linzhu Zhou, Yu Huang, Dongbo Guo, Dong Chen, Chuanlong Li, Aliya Aini, Xinyuan Zhu*. Supramolecular block copolymer for gene delivery: Enhancement of transfection efficacy by charge regulation. Chemical Communications 2017, 53, 12782−12785. (* Corresponding author) (IF = 6.222)
12. Wumaier Yasen, Ruijiao Dong*, Linzhu Zhou, Jieli Wu, Chengxi Cao, Aliya Aini, Xinyuan Zhu*. Synthesis of a cationic supramolecular block copolymer with covalent and noncovalent polymer blocks for gene delivery. ACS Applied Materials & Interfaces 2017, 9, 9006−9014. (* Corresponding author) (IF = 10.383)
13. Ruijiao Dong, Screenath P. Ravinathan, Lizhe Xue, Nan Li*, Yingjian Zhang, Linzhu Zhou, Chengxi Cao, Xinyuan Zhu*. Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging. Chemical Communications 2016, 52, 7950–7953. (IF = 6.222)
14. Ruijiao Dong, Yan Pang, Yue Su, Xinyuan Zhu*. Supramolecular hydrogels: Synthesis, properties and their biomedical applications. Biomaterials Science 2015, 3(7), 937–954. 2015's most accessed Biomaterials Science articles (IF = 7.59)
15. Ruijiao Dong, Yang Bo, Gangsheng Tong, Yongfeng Zhou, Xinyuan Zhu*, Yunfeng Lu*. Self-assembly and optical properties of a porphyrin-based amphiphile. Nanoscale 2014, 6, 4544–4550. (IF = 8.307)
16. Ruijiao Dong, Yue Su*, Songrui Yu, Yongfeng Zhou, Yunfeng Lu*, Xinyuan Zhu*. A redox-responsive cationic supramolecular polymer constructed from small molecules as a promising gene vector. Chemical Communications 2013, 49, 9845–9847. (IF = 6.222)
17. Ruijiao Dong, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. Reversible photoisomerization of azobenzene-containing polymeric systems driven by visible light. Polymer Chemistry 2013, 4, 912–915. One of the Most-Read Articles (January, 2013) (IF = 5.364)
18. Ruijiao Dong, Hongying Chen, Dali Wang, Yuanyuan Zhuang, Lijuan Zhu, Yue Su, Deyue Yan, Xinyuan Zhu*. Supramolecular fluorescent nanoparticles for targeted cancer imaging. ACS Macro Letters 2012, 1, 1208–1211. One of the Most-Read Articles (October, 2012) (IF = 7.015)
19. Ruijiao Dong, Linzhu Zhou, Jieli Wu, Chunlai Tu, Yue Su, Bangshang Zhu, Hongchen Gu, Deyue Yan, Xinyuan Zhu*. A supramolecular approach to the preparation of charge-tunable dendritic polycations for efficient gene delivery. Chemical Communications 2011, 47, 5473–5475. (IF = 6.222)
20. Ruijiao Dong, Yong Liu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. Photo-reversible supramolecular hyperbranched polymer based on host–guest interactions. Polymer Chemistry 2011, 2, 2771–2774. (IF = 5.364)
21. Ruijiao Dong, Jiongxin Zhao*, Youwei Zhang, Ding Pan. Morphology control of polyacrylonitrile (PAN) fibers by phase separation technique. Journal of Polymer Science Part B: Polymer Physics 2009, 47, 261–275. (IF = 3.151)
22. Ruijiao Dong, Marcus Keuser, Xiaomei Zeng, Jiongxin Zhao*, Youwei Zhang, Chengxun Wu, Ding Pan. Viscometric measurement of the thermodynamics of PAN terpolymer/DMSO/water system and effect of fiber-forming conditions on the morphology of PAN precursor. Journal of Polymer Science Part B: Polymer Physics 2008, 46, 1997–2011. (IF = 3.151)
23. Songrui Yu, Ruijiao Dong, Jianxin Chen, Feng Chen, Wenfeng Jiang, Yongfeng Zhou*, Xinyuan Zhu*, Deyue Yan. Synthesis and self-assembly of amphiphilic aptamer-functionalised hyperbranched multiarm copolymers for targeted cancer imaging. Biomacromolecules 2014, 15, 1828–1836. (IF = 6.978)
24. Yu Huang, Ruijiao Dong, Xinyuan Zhu*, Deyue Yan*. Photo-responsive polymeric micelles. Soft Matter 2014, 10, 6121–6138. (IF = 4.046)
25. Xuan Wei, Ruijiao Dong, Dali Wang, Tianyu Zhao, Yongsheng Gao, Patrick Duffy, Xinyuan Zhu*, Wenxin Wang*. Supramolecular fluorescent nanoparticles constructed via multiple non-covalent interactions for the detection of hydrogen peroxide in cancer cells. Chemistry–A European Journal 2015, 21(32), 11427–11434. (IF = 5.236)
26. Xiuying Huan, Dali Wang, Ruijiao Dong, Chunlai Tu, Bangshang Zhu*, Deyue Yan, Xinyuan Zhu*. Supramolecular ABC miktoarm star terpolymer based on host-guest inclusion complexation. Macromolecules 2012, 45, 5941–5947. (IF = 6.057)
27. Songrui Yu, Jianxin Chen, Ruijiao Dong, Yue Su, Bing Ji, Yongfeng Zhou*, Xinyuan Zhu*, Deyue Yan. Enhanced gene transfection efficiency of PDMAEMA by incorporating hydrophobic hyperbranched polymer cores: effect of degree of branching. Polymer Chemistry 2012, 3, 3324–3329. (IF = 5.364)
28. Dali Wang, Gangsheng Tong*, Ruijiao Dong, Yongfeng Zhou, Jian Shen*, Xinyuan Zhu*. Self-assembly of supramolecularly engineered polymers and their biomedical applications. Chemical Communications 2014, 50, 11994–12017. (IF = 6.222)
29. Hongping Deng, Yue Su, Minxi Hu, Xin Jin*, Lin He, Yan Pang, Ruijiao Dong, Xinyuan Zhu*. Multicolor fluorescent polymers inspired from green fluorescent protein. Macromolecules 2015, 48, 5969–5979. (IF = 6.057)

Principal Investigator (PI) for National Science Fund for Excellent Young Scholars (Overseas) (2022-2024), The Thousand Talents Program of Shanghai (2021), Starting Grant at Shanghai Jiao Tong University (2020-2022), National Natural Science Foundation of China (Grant No.: 22175114, 2022-2025), National Natural Science Foundation of China (Grant No.: 21504054, 2016-2018), Shanghai Natural Science Foundation of China (Grant No.: 22ZR1429400, 2022-2025), and Postdoctoral Science Foundation of China (Grant No.: 2015M580321, 2016), Taizhou High-level Innovative and Entrepreneurial Talent Program (2022-2023), Shanghai GeneSense Technology Inc. (2021), etc.
Main Participant for EPSRC Grant (2015-2017), ERC Advanced Grant (2018-2023), National Natural Science Foundation of China (2012-2014, 2014-2017), etc.

To obtain two PCT international patents, including “Defined monomer sequence polymers” (WO2017042583A1) and “Multi oligomer monomers in interfaciallly polymerised film” (GB2005106.6); To apply one China Invention Patent.

In our research group, there are 1 Postdoctoral Research Fellow, 3 PhD students, 4 Master students, and 4 Undergraduates.