Including learning experience
PhD in Genetics 2013
Shanghai Jiao Tong University School of Medicine, Shanghai,China
Master in Biochemistry and Molecular Biology 2008 Shanghai Jiao Tong University School of Medicine, Shanghai,China
B.M. in Pharmacology 2002
Fudan University, Shanghai,China

 

Work Experience
Postdoctoral fellow 2015.8-2017.8
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Research Associate 2013.8-2015.7/ Research Assistant 2008.8-2010.8/ Research Intern and Technician 2002.8-2004.8
Chinese National Human Genome Center at Shanghai

 

 

The aberrant ubiquitin ligase activity and the tumorigenesis; To explore the molecular mechanisms responsible for gastric cancer developmenter

2018-2022
1. Fu X#, Zhao J#, Yu G#, Zhang X, Sun J, Li L, Yin J, Niu Y, Ren S, Zhu Y*, Xu B*, Huang L*. OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR. Commun Biol. 2022 Mar 1;5(1):182. doi: 10.1038/s42003-022-03133-1. (#First author, *Corresponding author)
2. Li H#, Fu X#, Zhao J#, Li C#, Li L, Xia P, Guo J, Wei W, Zeng R, Wu J*, Sun Y*, Huang L*, Wang X*. EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal.Mol Cancer Res. 2022 Jul 6;20(7):1021-1034. doi: 10.1158/1541-7786.MCR-21-0441. (#First author, *Corresponding author)
3. Zhao J#, Fu X#, Chen H#, Min L, Sun J, Yin J, Guo J, Li H, Tang Z, Ruan Y*, Wang X*, Sun Y, Huang L*. G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer. Br J Cancer. 2021 Jan;124(2):425-436. ​(#First author, *Corresponding author)
4. Huang LY#,*, Zhao J#, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y*, Wei W*. SCFFBW7-mediated Degradation of Brg1 Suppresses Gastric Cancer Metastasis. Nat Commun. 2018 (#First author, *Corresponding author)
5. Huang LY#, Wang X#, Cui XF#, Li H, Zhao J, Wu CC, Min L, Zhou Z, Wan L, Wang YP, Zhang C, Gao WQ, Sun Y*, Han ZG*. IRTKS is correlated with progression and survival time of gastric cancer patients. Gut. 2018 Aug;67(8):1400-1409. doi: 10.1136/gutjnl-2016-313478. (#First author)
6. Wan L†, Xu K†, Wei Y†, Zhang J†, Han T, Fry C, Zhang Z, Wang V, Huang LY, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Wu Y, Liu J, Jin VX, Li J, Dai X, Guo J, Liu J, Asara JM , Brown M, Huang MC, Wei W. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024.

National Natural Science Foundation of China

PhD student (four)
Master student (one)