本课题组主要围绕肿瘤的诊断及治疗这一热点科学问题，致力于设计开发具有精准序列结构的多维高分子生物材料，以及其在药物递送、基因治疗、蛋白免疫治疗、生物成像等多个领域中的应用。旨在建立一套普适的平台技术，用以构建精准有序的纳米递送体系，研究载体与生物体的作用机制，可控调节其性能，进而优化其临床疗效。目前，本课题组在高分子化学、材料科学、生物医药等多个领域积累了丰富的研究基础和研发经验，已累计发表SCI论文30余篇，包括Science、Nature、Nature Chem.、Adv. Mater.、Acc. Chem. Res.、Angew. Chem. Int. Ed.、Chem. Commun.、ACS Appl. Mater. Interfaces、Nanoscale、ACS Macro Lett.等，论文SCI总引超 2000次，多篇论文入选ESI高被引论文及年度阅读量最高论文，相关成果得到了国际学术同行的认可，并被科学杂志、PHYS.ORG、MIRAGE新闻网、国际化学工程师协会（IChemE）、ACS Noteworthy Chemistry及X-MOL等作为研究亮点报道。
董瑞蛟，男，博士，开云官方在线登陆入口研究员、博士生导师、课题组长、院长助理。入选国家自然科学基金优秀青年科学基金（海外）、上海市海外高层次人才计划、江苏省333高层次人才培养工程等人才计划。主要围绕“高分子精准合成与功能调控机制”这一关键科学问题开展系统研究，聚焦功能高分子材料的可控构筑与构效调控，实现了其在药物递送、基因治疗、免疫治疗及膜分离等领域的应用。相关研究已累计发表学术论文40余篇，包括Nature、Science、Nat. Chem.、Nat. Water、Nat. Commun.、Angew. Chem. Int. Ed.、Adv. Mater.、Adv. Sci.、Nano Lett.、Chem. Soc. Rev.、Coord. Chem. Rev.、Acc. Chem. Res.等。现担任 Nano-Micro Letters、Polymer Science & Technology、Supramolecular Materials、Transformative Chemistry、Chain等国际学术期刊青年编委。近年来主持国家级及省部级科研项目10余项。同时，作为创始人或联合创始人先后创立了Exactmer（伦敦）有限公司、希坤新材料科技（泰州）有限公司及普睿信生物科技（丽水）有限公司，推动功能高分子材料在生物医药与先进分离领域的成果转化。
邮箱：drj021@sjtu.edu.cn
课题组成员：
助理研究员：于力
博士后：吴过
科研助理：宋开元
博士生：黄琦婧、陈玉、林清泉、刘嘉欣、权相宇、许多、杨尔鹏（联培）、袁哲（联培）
硕士生：王一鸣、缪镓镓、邵微、王克尧、周雨欣（联培）
主要研究方向
主要围绕肿瘤的诊断及治疗这一热点科学问题，致力于设计开发具有精准序列结构的多维高分子生物材料，以及其在药物递送、基因治疗、蛋白免疫治疗、生物成像、分子筛分、环境检测及治理等多个领域中的应用。旨在建立一套普适的平台技术，用以构建精准有序的纳米递送体系，研究载体与生物体的作用机制，可控调节其性能，进而优化其临床疗效。具体研究方向包括：
1. 全自动流动化学合成技术构建精准有序生物医用高分子材料
2. 精准蛋白药物、非病毒基因递送载体的开发及其与生物体作用机制研究
3. 多维有序共轭高分子材料的可控制备及生物应用研究
课题组网站：
http://www.donggroup.sjtu.edu.cn/Default.aspx
代表性成果
1. Xiangyu Quan, Baiyang Chen, Qijing Huang, Li Yu, Yue Su, Ang Gao, Yongfeng Zhou, Xinyuan Zhu, Jiang Wu, and RUIJIAO DONG*. Sequence- and topology-encoded polyporphyrin nanostructures with programmable stacking for enhanced photodynamic therapy. Angewandte Chemie International Edition 2026, In revision.
2. Qingquan Lin†, Kaiyuan Song†, Baiyang Chen, Yiming Wang, Li Yu, Yongfeng Zhou, Weilin Xu, Xinyuan Zhu*, Andrew G. Livingston, and RUIJIAO DONG*. In situ polymer-engineered aligned covalent organic framework membranes for precision polymer separation. Nature 2025, In revision.
3. Baiyang Chen†, Kaiyuan Song†, Li Yu†, Lujia You, Yiming Wang, Zhaoguo Zhang, Yongfeng Zhou, Xinyuan Zhu, and RUIJIAO DONG*. Controlled optically active hierarchical nanostructures of side-chain sequence-regulated graphene nanoribbons. Advanced Science 2026, 13(20), e23362. https://doi.org/10.1002/advs.202523362 (* Corresponding author)
4. Baiyang Chen†, Li Yu†, Kaiyuan Song, Xiangyu Quan, Yihan Liu, Ting Shi, Yongfeng Zhou, Xinyuan Zhu, and RUIJIAO DONG*. Discrete patterned polymeric nanostructures via controlled biaxial iterative synthesis. Nano Letters 2026, 26(1), 568-578. (* Corresponding author)
5. Bei Li, Ang Li*, Ping Li*, and RUIJIAO DONG*. Nanozyme-based colorimetric and fluorescent sensors: Catalytic mechanisms and hazardous pollutant detection in aquatic environment. Coordination Chemistry Reviews 2026, 546, 217062. (* Corresponding author)
6. Yu Chen†, Jia Xu†, Kaiyuan Song, Ziying Li, Baiyang Chen, Qijing Huang, Li Yu, Yue Su, and RUIJIAO DONG*. Hierarchically semi-interpenetrating polymer nanofilms for high-performance seawater desalination. Nature Water 2026, 4, 183–195. (* Corresponding author)
7. Bei Li, Ping Li*, and RUIJIAO DONG*. Recent advances in nanozyme-based materials for environmental pollutant detection and remediation. Materials Chemistry Frontiers 2025, 9, 935–952. (* Corresponding author)
8. Ziying Li, Kaiyuan Song, Yu Chen, Lujia You, Li Yu, Baiyang Chen, Qijing Huang, Zihang Yuan, Yaqin Xu, Yue Su, Lintai Da*, Xinyuan Zhu, and RUIJIAO DONG*. Sequence-encoded bioactive protein-multiblock polymer conjugates via quantitative one-pot iterative living polymerization. Nature Communications 2024, 15, 6729. https://doi.org/10.1038/s41467-024-51122-1 (* Corresponding author)
9. Yu Chen, Kaiyuan Song, Ziying Li, Yue Su, Baiyang Chen, Qijing Huang, Li Yu, Zeguang Han, Yongfeng Zhou, Xinyuan Zhu, Lintai Da, Jia Xu*, and RUIJIAO DONG*. Antifouling Asymmetric Block Copolymer Nanofilms via Freestanding Interfacial Polymerization for Efficient and Sustainable Water Purification. Angewandte Chemie International Edition 2024, 63(36), e202408345. (* Corresponding author)
10. Li Yu†*, Baiyang Chen†, Ziying Li†, Yue Su, Xuesong Jiang, Zeguang Han, Yongfeng Zhou, Deyue Yan, Xinyuan Zhu and RUIJIAO DONG*. Computer-aided automated flow chemical synthesis of polymers. Giant 2024, 18, 100252. (* Corresponding author) (IF = 7.0)
11. Li Yu†*, Baiyang Chen†, Ziying Li, Qijing Huang, Kaiyuan He, Yue Su,* Zeguang Han, Yongfeng Zhou, Xinyuan Zhu, Deyue Yan and RUIJIAO DONG*. Digital synthetic polymers for information storage. Chemical Society Reviews 2023, 52, 1529–1548. (* Corresponding author)
12. Wumaier Yasen*, Bei Li, Aliya Aini, Ziying Li, Yue Su, Linzhu Zhou*, Dongbo Guo, Qiuhui Qian, Dong Chen, Xinyuan Zhu, RUIJIAO DONG*. Visible Light-Guided Gene Delivery with Nonviral Supramolecular Block Copolymer Vectors. ACS Applied Materials & Interfaces 2023, 15(35), 41817–41827. (* Corresponding author)
13. Siyao Li, RUIJIAO DONG, Valentina-Elena Musteata, Jihoon Kim, Neel D. Rangnekar, J. R. Johnson, Bennett D. Marshall, Stefan Chisca, Jia Xu, Scott Hoy, Benjamin A. McCool, Suzana P. Nunes, Zhiwei Jiang*, Andrew G. Livingston*. Hydrophobic polyamide nanofilms provide rapid transport for crude oil separation. Science 2022, 377, 1555–1561.
14. Zhiwei Jiang†, RUIJIAO DONG†, Austin M. Evans, Niklas Biere, Mahmood A. Ebrahim, Siyao Li, Dario Anselmetti, William R. Dichtel, Andrew G. Livingston*. Aligned macrocycle pores in ultrathin films for accurate molecular sieving. Nature 2022, 609 (7925), 58–64. († Co-first Author)
15. Wumaier Yasena, RUIJIAO DONG*, Aliya Aini, Xinyuan Zhu*. Recent advances on supramolecular block copolymers for biomedical applications. Journal of Materials Chemistry B 2020, 8, 8219-8231. (* Corresponding author)
16. RUIJIAO DONG, Ruiyi Liu, Piers R. J. Gaffney, Marc Schaepertoens, Patrizia Marchetti, Christopher M. Williams, Rongjun Chen, Andrew G. Livingston*. Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving. Nature Chemistry 2019, 11, 136–145.
17. Wumaier Yasen, RUIJIAO DONG*, Linzhu Zhou, Jieli Wu, Chengxi Cao, Aliya Aini, Xinyuan Zhu*. Synthesis of a cationic supramolecular block copolymer with covalent and noncovalent polymer blocks for gene delivery. ACS Applied Materials & Interfaces 2017, 9, 9006−9014. (* Corresponding author)
18. Wumaier Yasen, RUIJIAO DONG*, Linzhu Zhou, Yu Huang, Dongbo Guo, Dong Chen, Chuanlong Li, Aliya Aini, Xinyuan Zhu*. Supramolecular block copolymer for gene delivery: Enhancement of transfection efficacy by charge regulation. Chemical Communications 2017, 53, 12782−12785. (* Corresponding author)
19. RUIJIAO DONG, Yongfeng Zhou, Xiaohua Huang, Xinyuan Zhu*, Yunfeng Lu, Jian Shen*. Functional supramolecular polymers for biomedical applications. Advanced Materials 2015, 27, 498–526.
20. RUIJIAO DONG, Yongfeng Zhou, Xinyuan Zhu*. Supramolecular dendritic polymers: From synthesis to applications. Accounts of Chemical Research 2014, 47, 2006–2016.
21. RUIJIAO DONG, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. "Breathing" vesicles with jellyfish-like on–off switchable fluorescence behavior. Angewandte Chemie International Edition 2012, 51, 11633–11637.
