课题组围绕心血管发育与再生、重大心血管疾病关键分子机制、基因编辑技术及基因治疗药物开发等方向开展研究，建立了涵盖基因组学、表观遗传组学、转录组学、转基因动物模型及生物信息学分析的研究平台。其团队在心血管发育调控、血管新生、疾病分子机制及转化治疗策略等方面形成了系统研究基础，近年来在 Cell Research、Circulation、Circulation Research、Journal of Clinical Investigation、Genome Research、Genome Biology 和 Blood 等国际期刊发表多项研究成果，并承担国家自然科学基金重点项目、科技部重点研发计划及上海市相关科研项目。

张冰，上海交通大学特聘教授、开云官方在线登陆入口兼职博导、国家杰青、国家高层次人才。获美国独立科学家奖。上海交大医学院新华医院罕见病基因和细胞治疗中心主任、先天性心脏病诊治技术与器械教育部工程研究中心副主任、心血管发育和再生研究所副所长。现为中国细胞生物学会发育生物学分会执委、上海市细胞生物学分会常务理事、上海市心血管衰老协会常务理事以及科技部、自然基金委和香港科技资助局的评审专家。“上海市高水平创新团队激励计划”负责人。先后获得国家自然基金重点项目、科技部重点研发专项、上海世界顶尖科学家国际联合科学实验室项目、上海市教委重点创新项目等多项基金支持。在Circulation、Cell Research 、Cell Stem Cell, Circulation Research、Nature Communications、Cell Reports等国际期刊上发表高水平论文合计六十余篇。

1. Junhao Xiong , Shasha Zhang, Zilong Geng , Juntao Lin, Kang Cheng, Huan Hu , Yuze Wang, Xing Liu, Yuanzhe Sheng, Ping Yang, Yige Li, Shuo Wu, Xiao Cheng, Yelan Li, Aijun Sun, Alex F Chen, Daowen Wang, Chen Chen , Yan Zhang, Gengze Wu , Chunyu Zeng , Xiaoling Guo , Xumin Hou, Ruogu Li , Yuliang Feng, Dan Zhu, Kun Sun, Bing Zhang*　An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure．Circulation 2025 Aug 18.doi: 10.1161/CIRCULATIONAHA.125.074845

2. Shasha Zhang , Kang Cheng , Junhao Xiong , Xing Liu , Juntao Lin , Huan Hu, Zilong Geng, Weimin Xu , Shizhan Xu , Ao Tan , Jin Zhang , Wenjuan Li , Zhizhao Guo , Ping Yang, Xiao Cheng, Tao Zhong , Xiaoling Guo, Lijun Fu , Min Zhang , Jinghai Chen, Gengze Wu, Lianpin Wu , Dan Zhu , Bing Zhang*. LARP7 promotes postnatal cardiac regeneration by facilitating G2/M phase transition. J Mol Cell Cardiol 2026 Feb 8:213:48-58. doi: 10.1016 (封面文章)

3. Ping Yang, Yingmei Lou, Zilong Geng, Zhizhao Guo, Shuo Wu, Yige Li, Kaiyuan Song, Ting Shi, Shasha Zhang, Junhao Xiong, Alex F Chen, Dali Li, William T. Pu, Lintai Da, Yan Zhang*, Kun Sun*, Bing Zhang*.Allele-specific suppression of mutant MHC with a high precision RNA nuclease CRISPR-Cas13d prevents hypertrophic cardiomyopathy. Circulation, 2024 doi: 10.1161/CIRCULATIONAHA.123.067890.(IF>39)

4.Shuo Wu, Ping Yang, Zilong Geng, Yige Li, Zhizhao Guo, Yingmei Lou, Shasha Zhang, Junhao Xiong, Huan Hu, Xiaoling Guo, William T. Pu, Yan Zhang, Dan Zhu, Bing Zhang*. Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice. Cell Res. 09 Feb. 2024, doi: 10.1038/s41422-024-00930-7 (IF>28)

5. Huan Hu, Zilong Geng, Shasha Zhang, Yuejuan Xu, Qingjie Wang, Sun Chen, Bing Zhang*, Kun Sun* and Yanan Lu*. Rare copy number variation analysis identifies disease-related variants in atrioventricular septal defect patients. Frontiers in Genetics. 03 February 2023, DOI 10.3389/fgene.2023.1075349 (IF>4)

6. Zilong Geng, Wenjuan Li, Ping Yang, Shasha Zhang, Shuo Wu, Junhao Xiong, Kun Sun, Dan Zhu, Sun Chen*,Bing Zhang*. Whole exome sequencing reveals genetic landscape associated with left ventricular outflow tract obstruction in Chinese Han population. Frontiers in Genetics, 2023. Dec （IF>4）
7. Yang P, Wu S, Li Y, Lou Y, Xiong J, Wang Y, Geng Z, Zhang B*. LARP7 overexpression alleviates aortic senescence and atherosclerosis. J Cell Mol Med. 2024 Jun;28(11):e18388. (IF>4)

8. Lou Y,Yang P, Wang Y, Liu X, Guo Z, Geng Z, Lin J, Wang J, Zhang M, Guo X, Fu L, Zhu D, Wu L, Zhang B*.Long-term therapeutic efficacy and safety profiles of hpCas13d RNA editing in treating early-onset hypertrophic cardiomyopathy. Life Sci. 2024 Oct 17;358:123144. doi: 10.1016/j.lfs.2024.123144. Online ahead of print. (IF>5)

9. Pengyi Yan, Zixuan li, Junhao Xiong, Zilong Geng, Weiting Wei, Yan Zhang, Gengze Wu, Tao Zhuang, Xiaoyu Tian, Zhijie Liu, Junling Liu, Kun Sun, Fengyuan Chen, Yuzhen Zhang, Chunyu Zeng, Yu Huang, Bing Zhang* LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Rep. 2021 Nov 23;37(8):110038. (IF>9)

10、 Xiaodong Liang, Shuo Wu, Zilong Geng, Li Liu, Shasha Zhang, Shiyan Wang, Yan Zhang, Yu Huang, Bing Zhang*, LARP7 suppresses endothelial-to-mesenchymal transition by coupling with TRIM28. Circulation Research, 2021 Sep 10.doi: 10.1161/CIRCRESAHA.121.319590. (IF>17)

11、Huijing Yu; Fang Zhang; Pengyi Yan; Shasha Zhang; Yingmei Lou; Zilong Geng; Zixuan Li; Yan Zhang; Yuejuan Xu; Yanan Lu; Chen Chen; Daowen Wang; Wei Zhu; Xinyang Hu; Jian’an Wang; Tao Zhuang; Yuzhen Zhang; Gengze Wu; Junling Liu; Chunyu Zeng; William T. Pu; Kun Sun; Bing Zhang*, LARP7 protects against heart failure by enhancing mitochondrial biogenesis, Circulation 2021 May 18;143(20):2007-2022. (IF>29)

12、Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Zeguang Han, William T Pu, Sun Chen, Yingwei Chen, Kun Sun, Baoxue Ge, Bing Zhang*. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18;32(7):108058. (IF>9)

13、Jiahuan Chen, Xiaodong Liang, Shasha Zhang, Shiyan Wang, Sara P. Garcia, Pengyi Yan, Huijing Yu, Zixuan Li, Li Liu, Fang Zhang, Weiting Wei, Huangying Le, Yan Zhang, Guo-cheng Yuan, Sun Chen, Yingwei Chen, Kun Sun, William T. Pu, Bing Zhang*,Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020, Jan 30;11(1):75. (IF>9)

14、Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC*, Pu WT*, Zhang B*. A dynamic and integrated epigenetic program at distal region orchestrates transcriptional responses to VEGFA. Genome Res. 2019 Feb;29(2):193-207. doi: 10.1101/gr.239053.118. (IF>10) (封面文章)

15、Wenhua Yu, Fang Zhang, Huafeng Xie, Shiyan Wang, Yi Fu, Jiahuan Chen, Xiaodong Liang, Huangying Le, William T. Pu*, Bing Zhang*. Depletion of Polycomb Repressive Complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 Apr 13;8(4):e2744. (IF>9)

16、Jiahuan Chen, Yi Fu, Daniel S. Day, Ye Sun, Shi-yan Wang, Xiaodong Liang, Fei Gu, Fang Zhang, Sean M. Stevens, Pingzhu Zhou, Kai Li, Yan Zhang, Ruei-zeng Lin, Lois E. H. Smith, Jin Zhang, Juan M. Melero-Martin, Ze-Guang Han, Peter J. Park, Bing Zhang*, William T. Pu* “VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 Aug 29;8(1):383. doi: 10.1038/s41467-017-00405-x. (IF>14)

17、Daniel Day, Zhang Bing*, Sean M. Stevens, Francesco Ferrari, Erica N. Larschan, Peter J Park*, William.T.PU*. Comphensive analysis of Promoter-Promximal RNA PolymeraseII Pasuing Across Mammlian Cell Types. Genome Biol. 2016 Jun 3;17(1):120. doi: 10.1186/s13059-016-0984-2. * co-first and co-corresponding author. (IF>13)

18、Zhang Bing, William. T. PU. Notching up vascular regeneration. Cell Research 2014; doi:10.1038/ cr.2014. (IF>25)

19、Zhang Bing, Wenyuan Xiao, Hong Qiu, Fuming Zhang, Eduard Condac, Cathy Cheng, Parastoo Azadi, John J. Greer, Dean Li, kelley Moremen, Robert Linhardt, Jeffrey D. Esko, Lianchun Wang. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.J Clin Invest. 2014 Jan 2;124(1):209-21. (IF>14)

20、Zhang Bing, Pu WT. The mysterious origins of coronary vessels. Cell Res. 2013 Jul 9.doi:10.1038/cr. 2013.90. (IF>25)

21、Bing Zhang, Daniel S. Day, Joshua W. Ho, Lingyun Song, Jingjing Cao, Danos Christodoulou, Jonathan G. Seidman, Gregory E. Crawford, Peter J. Park, and William T. Pu. A dynamic H3K27ac signature defines VEGFA-regulated endothelial enhancers. Genome Res. 2013 Jun;23(6):917-27. (IF>10)

22、Zhang Bing, Ursula M. Dietrich, Jian-Guo Geng, Roy Bicknell, Jeffrey D.Esko and Lianchun Wang. (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 5;114(19):4300-9. (IF>22)